Having visited Chile multiple times and spent time with Chilean friends, I’ve found the cultural differences between Chile and Argentina to be quite significant. Despite being neighbors, the two countries often don’t see eye to eye culturally or socially. While some might compare them to the U.S. and Canada, a more accurate comparison might be the U.S. and the U.K.—familiar in some ways, but distinctly different in tone, values, and social norms. (For a closer cultural match, Argentina and Uruguay are probably the better analogy.)
If culture isn’t a top priority for you, Chile could be a solid choice. In many ways—especially commercially and in terms of infrastructure—it feels more similar to the U.S.
That said, choosing between the two really depends on your own circumstances, preferences, and goals. If you’re looking for meaningful advice, the best starting point is to share a bit more about your background and what you’re hoping to find.