For what it's worth, I prefer staying near Plaza General San Martín, but it seems not everyone shares that sentiment for some reason.
This is a question that is asked a lot, so you can search for results in this forum.
Good Luck!
For our upcoming trip, my wife and I will spend three days in Buenos Aires and two days in the Argentinian Patagonia with a tour group. The package includes two dinners and two tours (a city tour and a visit to a gaucho ranch). We have approximately half of our time free to explore. We plan to...